The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) caused over 700 million deaths. SARS-CoV-2 continues to evolve, generating new variants of concern to evade the human humoral immune response. In this forthcoming seminar, I will delve into our efforts to unveil the mechanisms governing the co-evolution of neutralizing antibodies and
SARS-CoV-2.
The seminar will begin with an overview of the antibody response elicited by SARS-CoV-2, encompassing dominant epitopes, followed by our studies to unraveling convergent signatures and the dynamics of antigen-specific antibody repertoire, and finally the investigation on the structural basis of antibody neutralization and the pathways explored by the virus for evasion. At the end, I will discuss how the technologies and knowledge acquired through SARS-CoV-2 studies inform strategies for future pandemic preparedness

Presented by: Dr. Zizhang Sheng

CE eligible: yes