Reproductive Health

Dr. Troedsson’s research encompasses reproductive immunology, infertility and pregnancy loss in horses, and has contributed to advancements in the pathophysiology, diagnosis and treatment of equine endometritis, in particular breeding-induced endometritis and the role of seminal plasma proteins in the innate immune response to breeding. He has also contributed with pioneer research on early diagnostics and treatment of equine placentitis as well as other areas of reproductive health in mares and stallions. His former graduate students have obtained faculty positions and serve as academic leaders at US and International Universities. Dr. Troedsson is board certified in the American College of Theriogenology and the European College of Animal Reproduction, and has served in numerous leadership positions. Current and recent research include

• Bacterial biofilm associated proteins as potential diagnostics for endometritis
• Identification of biomarkers for high-risk pregnancies
• The effect of seminal plasma on immune tolerance during pregnancy, and metabolism of the offspring
• Degradation of endometrial cups by immune-modulatory treatment
• Pathophysiology of endometrial fibrosis 

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Scholars@UK

Publications:

Selected peer-reviewed publications during the last 3 years

170.*    Fedorka, C.E., Ball, B.A., Loux, S.L., Adams, A.A., Troedsson, M.H.T. (2020) Alterations in helper T cell transcripts at the feto-maternal interface throughout equine gestation. Placenta doi.org/10.1016/j.placenta.2019.10.011. 

171.*    Fedorka, C.E., Ball, B.A., Scoggin, K.E., Loux, S.C., Troedsson, M.H.T., Adams, A.A. (2019) The Feto-Maternal Immune Response to Equine Placentitis. Am. J. Reprod. Immunol. doi.org/10.1111/aji.13179.

172.      Cosgrove, E.J., Sadeghi, R., Schlamp, F., Holl, H.M., Moradi-Shahrbabak, M., Ashtiani, S.R.M., Abdalla, S., Shykind, B., Troedsson, M.H.T., Stefaniuk-Szmukier, M., Prabhu, A., Bucca, S., Bugno-Poniewierska, M., Wallner, B., Malek, J., Antczak, D.F., Miller, D.C., Clark, A.G., Brooks, S.A. (2020) Genome diversity and the origin of the Arabian horse. Scientific Reports/ Nature research doi.org 10.1038/s4 1598-020-66232-1.

173.*    Fedorka, C.E., Troedsson, M.H.T. (2020) The use of progestins in equine medicine: A review. Eq. Vet. Educ. dx.doi.org/10.1111/eve.13332.

174.*    Fedorka, C.E., Murase, H., Loux, S.C., Loynachan, A., Walker, O.F., Squires, E.L., Ball, B.A., Troedsson, M.H.T. (2020) The effect of mycobacterium cell wall fraction on histological, immunological, and clinical parameters of postpartum involution. Eq. Vet. Sci. doi.org/10.1016/j.jevs.2020.103013.

175.      Bucca, S., Sousa Oliviera, I.R., Cunanan, J., Vinardell, T. Troedsson, M.H.T. (2020) Doppler indices of the equine fetal carotid artery throughout gestation. Theriogenology doi.org/10.1016/j.theriogenology.2020.07.009

176.*    Fedorka, C.E., Scoggin, K.E., Loux, S.C., El-Sheikh Ali H., Dini, P., Troedsson, M.H.T., Ball, B.A. (2020) IL-6 pathobiology in acending placentitis. Am. J. Repr. Immun. doi: 10.1111/aji.13363.

177.      Esteller-Vico, A., Ball, B.A., Walter, J., Hughes, S., Squires, E.L., Troedsson, M.H.T. (2021) Changes in circulating concentrations of testosterone and estrone sulfate after human chorionic gonadotropin stimulation and subsequent to castration in two-year-old stallions. Anim. Reprod. Sci. https://doi.org/10.1016/j.anireprosci.2020.106670.

178.*    Fedorka, C.E., El-Sheikh Ali, H., Walker, O.F., Scoggin, K.E., Dini, P., Loux, S.C., Troedsson, M.H.T., Ball, B.A. (2021) The imbalance of the Th17/Treg axis involved in equine ascending placental infection. J. Reprod. Immunology. https://doi.org/10.1016/j.jri.2020.103268

179.*    Fedorka, C.E., Ball, B.A., Walker, O.F., McCormack, M.E., Scoggin, K.E., Kennedy, L., Squires, E.L., Troedsson, M.H.T. (2021) Alterations of Circulating Markers During Late Term Pregnancy Complications in the Horse. Part I: Cytokines. J. Eq. Vet. Sci. https://doi.org/10.1016/j.jevs.2021.103425

180.*    Fedorka, C.E., Ball, B.A., Wynn, M.A.A., McCormack, M.E., Scoggin, K.E., Esteller-Vico, A., Curry, T., Kennedy, L., Squires, E.L., Troedsson, M.H.T. (2021) Alterations of Circulating Markers During Late Term Pregnancy Complications in the Horse. Part II: Steroid Hormones and AFP. J. Eq. Vet. Sci. doi:10.1016/j.jevs.2021.103395

181.      Shingo, H., Dini, P., Esteller-Vico, A., Scoggin, K.E., Squires, E.L., Troedsson, M.H.T., Daels, P., Nambo, Y., Ball, B.A. (2021) Estrogen-regulated angiogenesis in the equine placenta. Int. J. Mol. Sc. doi.org/103390/ijms222212116

182.      de la Fuente, A., Scoggin, C., Bradecamp, E., Ali, H., Troedsson, M.H.T., Meyers, S., Dini, P. (2021) Transcriptome characterization of equine oocyte maturation. Reprod. Fert. Develop. doi.org/10.1071/RDv34n2Ab146

183.*    Fedorka, C.F., Troedsson, M.H.T. (2021) The use of immunomodulators in equine reproduction. Clin. Theriogenology 13:238-246.

184.*    Miller, L.M.J., Woodward, E.M. Campos, J.R., Williams, N., Squires, E.L., Troedsson, M.H.T. Expression of Sperm Protein at 22kDa (SP22) on spermatozoa and in the stallion’s reproductive tract prior to and following heat-induced testicular regulation. Andrology (submitted).

185.*    Fedorka, C.E., El-Sheikh Ali, H., Scoggin, K.E., Loux, S.C., Ball, B.A., Troedsson, M.H.T. (2022) TNF signaling during equine placental infection leads to pro-apoptotic and necroptotic outcomes. Am. J. Repr. Immun. https://doi.org/10.1016/j.jri.2022.103655.

186.      Williams, N.J., Slovis, N.M., Browne, N.S., Troedsson, M.H.T., Giguėre, S., Hernandez, J.A. Enterococcus durans infection and diarrhea in Thoroughbred foals. J. Vet. Int. Med. https://doi.org/10.1111/jvim.16568 

187.      Alghamdi, A.S., Fedorka, C.E., Scoggin, K.E., Vico, A.E., Beatty, K., Davolli, G., Ball, B.A., Troedsson, M.H.T. (2023) Binding of equine seminal llactoferrin/ superoxide dismutase (SOD-3) complex is biased towards dead spermatozoa. Animals 13(1), 52; https://doi.org/10.3390/ani13010052.

188.      Fedorka, C.E., El-Sheikh Ali, H., Ball, B.A., Troedsson, M.H.T. (2023) Galectinology of equine pregnancy. Animals 13(1), 129; https://doi.org/10.3390/ani13010129

189.      Fedorka, C.E., El-Sheikh Ali, H., Ball, B.A., Troedsson, M.H.T. Galectinology of equine placental disease. Vet. Sci. https://doi.org/10.3390/vetsci10030218

190.      Fedorka, C.E., Troedsson, M.H.T. The Immune Response to Ascending Placentitis: A Review. Theriogenology https://doi.org/10.1016/j/theriogenology.2023.03.002

 * graduate student or a resident as first author